噪声的去除或取消对成像和声学具有广泛的应用。在日常生活中，Denoising甚至可能包括对地面真理不忠的生成方面。但是，对于科学应用，denoing必须准确地重现地面真相。在这里，我们展示了如何通过深层卷积神经网络来定位数据，从而以定量精度出现弱信号。特别是，我们研究了晶体材料的X射线衍射。我们证明，弱信号是由电荷排序引起的，在嘈杂的数据中微不足道的信号，在DeNo的数据中变得可见和准确。通过对深度神经网络的监督培训，具有成对的低噪声数据，可以通过监督培训来实现这一成功。这样，神经网络就可以了解噪声的统计特性。我们证明，使用人造噪声（例如泊松和高斯）不会产生这种定量准确的结果。因此，我们的方法说明了一种实用的噪声过滤策略，可以应用于具有挑战性的获取问题。

这是一门专门针对STEM学生开发的介绍性机器学习课程。我们的目标是为有兴趣的读者提供基础知识，以在自己的项目中使用机器学习，并将自己熟悉术语作为进一步阅读相关文献的基础。在这些讲义中，我们讨论受监督，无监督和强化学习。注释从没有神经网络的机器学习方法的说明开始，例如原理分析，T-SNE，聚类以及线性回归和线性分类器。我们继续介绍基本和先进的神经网络结构，例如密集的进料和常规神经网络，经常性的神经网络，受限的玻尔兹曼机器，（变性）自动编码器，生成的对抗性网络。讨论了潜在空间表示的解释性问题，并使用梦和对抗性攻击的例子。最后一部分致力于加强学习，我们在其中介绍了价值功能和政策学习的基本概念。

ICECUBE是一种用于检测1 GEV和1 PEV之间大气和天体中微子的光学传感器的立方公斤阵列，该阵列已部署1.45 km至2.45 km的南极的冰盖表面以下1.45 km至2.45 km。来自ICE探测器的事件的分类和重建在ICeCube数据分析中起着核心作用。重建和分类事件是一个挑战，这是由于探测器的几何形状，不均匀的散射和冰中光的吸收，并且低于100 GEV的光，每个事件产生的信号光子数量相对较少。为了应对这一挑战，可以将ICECUBE事件表示为点云图形，并将图形神经网络（GNN）作为分类和重建方法。 GNN能够将中微子事件与宇宙射线背景区分开，对不同的中微子事件类型进行分类，并重建沉积的能量，方向和相互作用顶点。基于仿真，我们提供了1-100 GEV能量范围的比较与当前ICECUBE分析中使用的当前最新最大似然技术，包括已知系统不确定性的影响。对于中微子事件分类，与当前的IceCube方法相比，GNN以固定的假阳性速率（FPR）提高了信号效率的18％。另外，GNN在固定信号效率下将FPR的降低超过8（低于半百分比）。对于能源，方向和相互作用顶点的重建，与当前最大似然技术相比，分辨率平均提高了13％-20％。当在GPU上运行时，GNN能够以几乎是2.7 kHz的中位数ICECUBE触发速率的速率处理ICECUBE事件，这打开了在在线搜索瞬态事件中使用低能量中微子的可能性。

机器人辅助手术现已在临床实践中成熟，已成为几种临床适应症的黄金标准临床治疗选择。有机器人辅助手术的领域预计将在未来十年内大幅增长，其中一系列新的机器人设备出现以解决不同专业的未满足临床需求。充满活力的手术机器人研究界是概念化这种新系统的关键，以及开发和培训工程师和科学家们将它们转化为实践。 Da Vinci研究套件（DVRK），学术界和行业合作努力重新登记达芬奇外科系统（直观的Surgical Inc，USA）作为用于外科机器人研究的研究平台，是解决A的关键倡议在外科机器人中进入新研究群体的障碍。在本文中，我们对过去十年来的DVRK促进的出版物进行了广泛的审查。我们将研究努力分类为不同的类别，并概述了机器人社区的一些主要挑战和需求，以维护这一倡议并建立在它上面。

Calculating an Air Quality Index (AQI) typically uses data streams from air quality sensors deployed at fixed locations and the calculation is a real time process. If one or a number of sensors are broken or offline, then the real time AQI value cannot be computed. Estimating AQI values for some point in the future is a predictive process and uses historical AQI values to train and build models. In this work we focus on gap filling in air quality data where the task is to predict the AQI at 1, 5 and 7 days into the future. The scenario is where one or a number of air, weather and traffic sensors are offline and explores prediction accuracy under such situations. The work is part of the MediaEval'2022 Urban Air: Urban Life and Air Pollution task submitted by the DCU-Insight-AQ team and uses multimodal and crossmodal data consisting of AQI, weather and CCTV traffic images for air pollution prediction.

In manufacturing, the production is often done on out-of-the-shelf manufacturing lines, whose underlying scheduling heuristics are not known due to the intellectual property. We consider such a setting with a black-box job-shop system and an unknown scheduling heuristic that, for a given permutation of jobs, schedules the jobs for the black-box job-shop with the goal of minimizing the makespan. Here, the jobs need to enter the job-shop in the given order of the permutation, but may take different paths within the job shop, which depends on the black-box heuristic. The performance of the black-box heuristic depends on the order of the jobs, and the natural problem for the manufacturer is to find an optimum ordering of the jobs. Facing a real-world scenario as described above, we engineer the Monte-Carlo tree-search for finding a close-to-optimum ordering of jobs. To cope with a large solutions-space in planning scenarios, a hierarchical Monte-Carlo tree search (H-MCTS) is proposed based on abstraction of jobs. On synthetic and real-life problems, H-MCTS with integrated abstraction significantly outperforms pure heuristic-based techniques as well as other Monte-Carlo search variants. We furthermore show that, by modifying the evaluation metric in H-MCTS, it is possible to achieve other optimization objectives than what the scheduling heuristics are designed for -- e.g., minimizing the total completion time instead of the makespan. Our experimental observations have been also validated in real-life cases, and our H-MCTS approach has been implemented in a production plant's controller.

The findable, accessible, interoperable, and reusable (FAIR) data principles have provided a framework for examining, evaluating, and improving how we share data with the aim of facilitating scientific discovery. Efforts have been made to generalize these principles to research software and other digital products. Artificial intelligence (AI) models -- algorithms that have been trained on data rather than explicitly programmed -- are an important target for this because of the ever-increasing pace with which AI is transforming scientific and engineering domains. In this paper, we propose a practical definition of FAIR principles for AI models and create a FAIR AI project template that promotes adherence to these principles. We demonstrate how to implement these principles using a concrete example from experimental high energy physics: a graph neural network for identifying Higgs bosons decaying to bottom quarks. We study the robustness of these FAIR AI models and their portability across hardware architectures and software frameworks, and report new insights on the interpretability of AI predictions by studying the interplay between FAIR datasets and AI models. Enabled by publishing FAIR AI models, these studies pave the way toward reliable and automated AI-driven scientific discovery.

Out-of-distribution detection is crucial to the safe deployment of machine learning systems. Currently, the state-of-the-art in unsupervised out-of-distribution detection is dominated by generative-based approaches that make use of estimates of the likelihood or other measurements from a generative model. Reconstruction-based methods offer an alternative approach, in which a measure of reconstruction error is used to determine if a sample is out-of-distribution. However, reconstruction-based approaches are less favoured, as they require careful tuning of the model's information bottleneck - such as the size of the latent dimension - to produce good results. In this work, we exploit the view of denoising diffusion probabilistic models (DDPM) as denoising autoencoders where the bottleneck is controlled externally, by means of the amount of noise applied. We propose to use DDPMs to reconstruct an input that has been noised to a range of noise levels, and use the resulting multi-dimensional reconstruction error to classify out-of-distribution inputs. Our approach outperforms not only reconstruction-based methods, but also state-of-the-art generative-based approaches.

胰腺癌是与癌症相关死亡的全球主要原因之一。尽管深度学习在计算机辅助诊断和检测方法（CAD）方法中取得了成功，但很少关注胰腺癌的检测。我们提出了一种检测胰腺肿瘤的方法，该方法在周围的解剖结构中利用临床上的特征，从而更好地旨在利用放射科医生的知识，而不是其他常规的深度学习方法。为此，我们收集了一个新的数据集，该数据集由99例胰腺导管腺癌（PDAC）和97例没有胰腺肿瘤的对照病例组成。由于胰腺癌的生长模式，肿瘤可能总是可见为低音病变，因此，专家指的是二次外部特征的可见性，这些特征可能表明肿瘤的存在。我们提出了一种基于U-NET样深的CNN的方法，该方法利用以下外部次要特征：胰管，常见的胆管和胰腺以及处理后的CT扫描。使用这些功能，该模型如果存在胰腺肿瘤。这种用于分类和本地化方法的细分实现了99％的敏感性（一个案例）和99％的特异性，这比以前的最新方法的灵敏度增加了5％。与以前的PDAC检测方法相比，该模型还以合理的精度和较短的推理时间提供位置信息。这些结果提供了显着的性能改善，并强调了在开发新型CAD方法时纳入临床专家知识的重要性。

我们介绍了DeepNash，这是一种能够学习从头开始播放不完美的信息游戏策略的自主代理，直到人类的专家级别。 Stratego是人工智能（AI）尚未掌握的少数标志性棋盘游戏之一。这个受欢迎的游戏具有$ 10^{535} $节点的巨大游戏树，即，$ 10^{175} $倍的$倍于GO。它具有在不完美的信息下需要决策的其他复杂性，类似于德克萨斯州Hold'em扑克，该扑克的游戏树较小（以$ 10^{164} $节点为单位）。 Stratego中的决策是在许多离散的动作上做出的，而动作与结果之间没有明显的联系。情节很长，在球员获胜之前经常有数百次动作，而Stratego中的情况则不能像扑克中那样轻松地分解成管理大小的子问题。由于这些原因，Stratego几十年来一直是AI领域的巨大挑战，现有的AI方法几乎没有达到业余比赛水平。 Deepnash使用游戏理论，无模型的深钢筋学习方法，而无需搜索，该方法学会通过自我播放来掌握Stratego。 DeepNash的关键组成部分的正则化NASH Dynamics（R-NAD）算法通过直接修改基础多项式学习动力学来收敛到近似NASH平衡，而不是围绕它“循环”。 Deepnash在Stratego中击败了现有的最先进的AI方法，并在Gravon Games平台上获得了年度（2022年）和历史前3名，并与人类专家竞争。